发明名称 |
Water soluble metal and semiconductor nanoparticle complexes and method for determining the progeny of target cells |
摘要 |
<p>The invention provides a water soluble complex comprising an inner core of a metal or semi-conductor nanoparticle. The nanoparticle is coated with a hydrophobic ligand, which is encapsulated in a micelle. In an aqueous medium, the micelle comprises a hydrophilic shell and a hydrophobic core, the hydrophilic shell comprising a plurality of hydrophilic moieties, the hydrophobic core comprising a plurality of hydrophobic moieties, each hydrophobic moiety comprising at least one chain, each chain comprising a minimum of 8 atoms; wherein the total number of atoms in all chains for each moiety comprises at least 24 atoms. The micelle has a minimum average diameter of approximately 5 nm and a maximum average diameter of approximately 45 nm.</p> |
申请公布号 |
EP1579506(B1) |
申请公布日期 |
2013.05.15 |
申请号 |
EP20030815180 |
申请日期 |
2003.08.07 |
申请人 |
THE ROCKEFELLER UNIVERSITY |
发明人 |
DUBERTRET, BENOIT;NOIREAUX, VINCENT;LIBCHABER, ALBERT |
分类号 |
G01N33/92;A61K9/127;A61K47/48;A61K49/00;H01F1/00;H01F1/36;H01F1/37 |
主分类号 |
G01N33/92 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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