发明名称 |
Nanoparticle compositions for generation of regulatory T cells and treatment of autoimmune diseases and other chronic inflammatory conditions |
摘要 |
<p>The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core.</p> |
申请公布号 |
EP2591801(A1) |
申请公布日期 |
2013.05.15 |
申请号 |
EP20110009032 |
申请日期 |
2011.11.14 |
申请人 |
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF;UNIVERSITAET HAMBURG;HEINRICH-PETTE-INSTITUT LEIBNIZ-INSTITUT FUER EXPERIMENTELLE VIROLOGIE-STIFTUNG BUERGERLICHEN RECHTS - |
发明人 |
HERKEL, JOHANNES;CARAMBIA, ANTONELLA;FREUND, BARBARA;HEEREN, JOERG;NIELSEN, PETER;BRUNS, OLIVER;LOHSE, ANSGAR;LUETH, STEFAN;WELLER, HORST;SALMEN, SUNHILD |
分类号 |
A61K39/39;A61K9/00;A61K9/107;A61K9/14;A61K9/50;A61K9/51;A61K47/48 |
主分类号 |
A61K39/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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