发明名称 |
Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
摘要 |
The invention provides compounds, compositions and methods to treat certain inflammatory conditions and/or oncology by administering a compound that inhibits PI3K isoforms, particularly the delta isoform. It further provides specific stereoisomers of a compound useful for these methods. In particular, the compound is an optically active atropisomer of 2-((6-amino-9H-purin-9-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one. |
申请公布号 |
US8440677(B2) |
申请公布日期 |
2013.05.14 |
申请号 |
US20100731089 |
申请日期 |
2010.03.24 |
申请人 |
EVARTS JERRY B.;ULRICH ROGER G.;GILEAD CALISTOGA LLC |
发明人 |
EVARTS JERRY B.;ULRICH ROGER G. |
分类号 |
C07D473/34;A61K31/52;A61P19/02 |
主分类号 |
C07D473/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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