发明名称 |
Clearance of abnormal IGA1 in IGA1 deposition diseases |
摘要 |
The present invention relates to proteins which specifically bind to IgA1 and which have been modified to comprise either O- or N-linked glycans. The invention encompasses methods for decreasing IgA1, preferably abnormally glycosylated IgA1, in an individual by administering to the individual a glycan-modified IgA1 binding protein of the invention. The invention also encompasses a method for the treatment of a disease characterized by IgA1 deposition wherein a glycan-modified IgA1 binding protein is administered to an individual in need thereof. |
申请公布号 |
US8440191(B2) |
申请公布日期 |
2013.05.14 |
申请号 |
US20060094145 |
申请日期 |
2006.11.17 |
申请人 |
PLAUT ANDREW G.;QIU JIAZHOU;TUFTS MEDICAL CENTER |
发明人 |
PLAUT ANDREW G.;QIU JIAZHOU |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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