发明名称 |
Antibody variants |
摘要 |
This invention relates to an antibody which is modified version of a therapeutic antibody with affinity for a cell-surface antigen, the antibody having reduced affinity for the antigen compared with the therapeutic antibody as a result of a modification or modifications to the antibody molecule, wherein the antibody is capable of inducing immunological tolerance to the therapeutic antibody. The invention further relates to a method of inducing immunological tolerance to a therapeutic antibody, comprising administering to a patient an antibody which is a modified version of the therapeutic antibody and which has reduced affinity for the antigen as compared with the therapeutic antibody. |
申请公布号 |
US8440190(B2) |
申请公布日期 |
2013.05.14 |
申请号 |
US20050180631 |
申请日期 |
2005.07.14 |
申请人 |
WALDMANN HERMAN;GILLILAND LISA K;TONE MASAHIDE;FREWIN MARK R;WALSH LOUISE;ISIS INNOVATION LIMITED |
发明人 |
WALDMANN HERMAN;GILLILAND LISA K;TONE MASAHIDE;FREWIN MARK R;WALSH LOUISE |
分类号 |
A61K39/00;C12N15/09;A61K31/00;A61K38/00;A61K39/395;A61P37/00;A61P37/02;C07K16/28;C07K16/46;C12P21/08 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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