发明名称 Pyrido[3,2-d]pyrimidine PI3K delta inhibitor compounds and methods of use
摘要 Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
申请公布号 US8440651(B2) 申请公布日期 2013.05.14
申请号 US201113030246 申请日期 2011.02.18
申请人 CASTANEDO GEORGETTE;CHAN BRYAN;LUCAS MATTHEW C.;SAFINA BRIAN;SUTHERLIN DANIEL P.;SWEENEY ZACHARY;F. HOFFMANN-LA ROCHE AG 发明人 CASTANEDO GEORGETTE;CHAN BRYAN;LUCAS MATTHEW C.;SAFINA BRIAN;SUTHERLIN DANIEL P.;SWEENEY ZACHARY
分类号 A61K31/397;A61K31/5377;C07D413/14 主分类号 A61K31/397
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