发明名称 |
ANTI-VEGF SINGLE VARIABLE DOMAINS FUSED TO FC DOMAINS |
摘要 |
The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD), diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs. |
申请公布号 |
WO2013014208(A3) |
申请公布日期 |
2013.05.10 |
申请号 |
WO2012EP64632 |
申请日期 |
2012.07.25 |
申请人 |
GLAXO GROUP LIMITED;ASHMAN, CLAIRE;CATCHPOLE, IAN RICHARD;HUGHES-THOMAS, ZOE;LEWIS, ALAN PETER;STEWARD, MICHAEL |
发明人 |
ASHMAN, CLAIRE;CATCHPOLE, IAN RICHARD;HUGHES-THOMAS, ZOE;LEWIS, ALAN PETER;STEWARD, MICHAEL |
分类号 |
C07K16/22;A61P27/02 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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