| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to pharmaceutics, namely to allergens purified from apitoxin and derived allergoids for immunotherapy of individuals suffering specific allergic reactions. The allergens for immunotherapy are prepared by dialysis of native apitoxin with using a membrane with cut-off 10 kDa, and represent apitoxin substantially mellitin-free. The apitoxin allergoids for immunotherapy prepared by carbamylation or thiocarbamylation or treatment to form guanidine groups of primary amino groups of protein portions of mellitin-depleted apitoxin. The pharmaceutical composition for immunotherapy on the basis of apitoxin which contains an effective immunotherapeutic dose of the allergen or allergoid together with pharmaceutically acceptable excipients. The use of the allergens or allergoids for preparing a drug preparation for immunotherapy.EFFECT: agents described above are effective for immunotherapy.15 cl, 6 dwg, 1 tbl, 2 ex |
