USE OF MIRNA 126 TO PRODUCE HEMATOPOIETIC STEM CELLS

摘要

What is described is a method for modulating the phenotype of a stem progenitor cell (SPC), including hematopoietic SPC (HSPC), comprising contacting the stem-progenitor cell with one or more nucleic acid molecules, in which each of the nucleic acid molecules comprises a nucleotide sequence that is at least about 90% identical to a sequence of miR126 (e.g., SEQ ID NOs: 1 or 2), or the complements thereof. Upon such contact, expression VCAM-1 is inhibited, resulting in mobilization of SPC. The miR126 nucleic acids may be administered to a healthy subject, and blood cells may be collected from the subject and used for allogeneic transplantation with greater ease than current procedures.