PEPTIDE-HINGE-FREE FLEXIBLE ANTIBODY-LIKE MOLECULE

摘要

Provided is an antibody capable of binding to a target with higher affinity. A peptide-hinge-free flexible antibody-like molecule containing a peptide-hinge-free group represented by general formula (I): XY-Asp-Lys-Thr-His-Thr (SEQ ID NO: 1) (in the formula, X represents a peptide constructed from 2-50 amino acid residues or an amino acid, and Y represents an alkylene oxide-containing group) and an antibody Fc fragment bound to this peptide-hinge-free group.