SINGLE NUCLEOTIDE POLYMORPHISMS ASSOCIATED IN LEFT VENTRICULAR HYPERTROPHY AND USE THEREOF

摘要

PURPOSE: A kit for diagnosing left ventricular hypertrophy and a method for detecting a marker for left ventricular hypertrophy are provided to diagnose left ventricular hypertrophy or cardiovascular diseases through analysis of SNP related to left ventricular hypertrophy. CONSTITUTION: A kit for diagnosing left ventricular hypertrophy contains a primer or a probe which specifically binds to 10-100 continuous nucleotide sequences containing one or more SNP sites selected from the group consisting of: 301th site of sequence number 1, 201th site of sequence number 2, and 201th site of sequence number 3 as SNP sites of RYR1(ryanodine receptor 1) gene; 201th site of sequence number 4 as an SNP site of DRD1(dopamine receptor D1); 256th site of sequence number 5 as an SNP site of TTRAP(toll-interleukin 1 receptor domain containing adaptor protein); 201th site of sequence number 6, 502th site of sequence number 7, 301th site of sequence number 8, and 960th site of sequence number 9 as SNP sites of FAM135B(family with sequence similarity 135, member B) gene; 301th site of sequence number 10 as an SNP site of GALNTL4(UDP-N-acetyl-alpha-Dgalactosamine: polypeptide N-acetylgalactosaminyltransferase-like 4); 251th site of sequence number 11 as an SNP site of DYNC2H1 (dynein, cytoplasmic 2, heavy chain 1) gene; and 401th base of sequence number 12 as an SNP site of DNAJC7 (DnaJ (Hsp40) homolog, subfamily C, member 7).