发明名称 |
HUMANIZED IL-6 AND IL-6 RECEPTOR |
摘要 |
Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6Ralpha locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus. |
申请公布号 |
US2013117873(A1) |
申请公布日期 |
2013.05.09 |
申请号 |
US201213662880 |
申请日期 |
2012.10.29 |
申请人 |
REGENERON PHARMACEUTICALS, INC.;REGENERON PHARMACEUTICALS, INC. |
发明人 |
WANG LI-HSIEN;DORE, JR. ANTHONY T.;STEVENS SEAN;MURPHY ANDREW J. |
分类号 |
A01K67/027 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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