BILAYER TABLET COMPRISING TELMISARTAN AND DIURETIC

摘要

PROBLEM TO BE SOLVED: To provide a bilayer pharmaceutical tablet comprising a first layer containing 3 to 50 mass% of telmisartan dispersed in a dissolving tablet matrix and a second layer containing a diuretic in a disintegrating tablet matrix as well as a processes for producing same.

SOLUTION: There are provided the bilayer pharmaceutical tablet comprising a first layer containing 3 to 50 mass% of telmisartan dispersed in a dissolving matrix comprising (a) a basic agent in a molar ratio of basic agent: telmisartan=1:1 to 10:1, (b) a surfactant or emulsifier in an amount of about 1 to 20 mass% of the final composition, (c) 25 to 70 mass% of a water-soluble diluent, and (d) optionally 0 to 20 mass% of further excipients and/or adjuvants, the sum of all components of the layer adding to 100% and a second layer containing a diuretic in a disintegrating tablet matrix.

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