发明名称 |
CLEAN, HIGH-YIELD PREPARATION OF S,S AND R,S AMINO ACID ISOSTERES |
摘要 |
The present invention provides compounds and methods that can be used to convert the intermediate halomethyl ketones (HMKs), e.g., chloromethyl ketones, to the corresponding S,S- and R,S-diastereomers. More particularly, the present invention provides: (1) reduction methods; (2) inversion methods; and (3) methods involving the epoxidation of alkenes. Using the various methods of the present invention, the R,S-epoxide and the intermediary compounds can be prepared reliably, in high yields and in high purity.
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申请公布号 |
US2013116457(A1) |
申请公布日期 |
2013.05.09 |
申请号 |
US201213490706 |
申请日期 |
2012.06.07 |
申请人 |
MALIK ASLAM A.;CLEMENT TODD E.;PALANDOKEN HASAN;ROBINSON, III JAMES;STRINGER JOY A.;AEROJET FINE CHEMICALS LLC |
发明人 |
MALIK ASLAM A.;CLEMENT TODD E.;PALANDOKEN HASAN;ROBINSON, III JAMES;STRINGER JOY A. |
分类号 |
C07C271/22;C07C213/00;C07C215/08;C07D263/20;C07D301/27;C07D303/36 |
主分类号 |
C07C271/22 |
代理机构 |
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主权项 |
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地址 |
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