发明名称 |
Process for the industrial - scale purification of gamma globulins from human plasma for industrial applications |
摘要 |
The invention relates to a novel, industrial-scale process for the purification of gamma-immunoglobulins (IgG) starting from plasma or fractions thereof. The method involves two chromatographic steps, i.e. a cation exchange capture chromatography, and then a polishing anion exchange chromatography, ensuring a highly purified end product, which contains no aggregates, and high yields. The process also involves a virus inactivation step by means of a solvent/detergent treatment to inactivate the viruses with a lipid envelope, and a virus removal step by nanofiltering to ensure the removal of the non-enveloped viruses. |
申请公布号 |
AU2010337871(B2) |
申请公布日期 |
2013.05.09 |
申请号 |
AU20100337871 |
申请日期 |
2010.12.28 |
申请人 |
KEDRION S.P.A. |
发明人 |
NARDINI, CLAUDIA;MORELLI, ANDREA;FARINA, CLAUDIO;ESPOSITO, SABRINA;LAZZAROTTI, ALESSANDRA;PETRUCCI, ARIANNA |
分类号 |
C07K16/06 |
主分类号 |
C07K16/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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