发明名称 |
METHOD OF PRODUCING LIPID NANOPARTICLES FOR DRUG DELIVERY |
摘要 |
What is described is a method for preparing a liposome that efficiently encapsulates a negatively charged therapeutic polymer, e.g., siRNA. The process involves preparing a lipid mixture comprising a cationic lipid in a water miscible organic solvent, such as ethanol, at a concentration of 2.3 mg/ml, and adding this solution to the polymer dissolved in water to a final concentration of 35% ethanol in water. The final charge ratio of drug:lipid is 1:2.5. The resulting nanoparticles have a mean size of 50 to 150 nm.
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申请公布号 |
US2013115274(A1) |
申请公布日期 |
2013.05.09 |
申请号 |
US201213669078 |
申请日期 |
2012.11.05 |
申请人 |
NITTO DENKO CORPORATION;NITTO DENKO CORPORATION |
发明人 |
KNOPOV VICTOR;WITTE RICHARD P.;KARMALI PRIYA;LEE ROBIN;WEBB DAVID;AKOPIAN VIOLETTA |
分类号 |
A61K9/127;A61K31/7105;B82Y5/00;B82Y40/00 |
主分类号 |
A61K9/127 |
代理机构 |
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地址 |
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