| 摘要 |
A protective group represented by the following general formula (I) (the oxygen atom attached with * represents oxygen atom of 2'-hydroxyl group of a ribonucleoside, a ribonucleotide or a derivative thereof, R 1 and R 2 both represent hydrogen atom, or represent a halogen atom, a C 1-6 alkyl group, or a C 1-6 halo-substituted alkyl group; R 3 and R 4 represent hydrogen atom, a halogen atom, a C 1-6 alkyl group, or a C 1-6 halo-substituted alkyl group; and R 5 and R 6 represent a halogen atom, a C 1-6 halo-substituted alkyl group, cyano group, nitro group, or the like), which is stable under the reaction conditions of the nucleic acid synthetic cycles and has little steric hindrance, and can be removed under mild conditions using fluoride ions as a base. |
