ANTICANCER COMPOSITION CONTAINIG THE NAPHTHALENYLPHENYLDIHYDROPYRAZOLE

摘要

PURPOSE: An anticancer composition containing naphthalenyl phenyl dihydropyrazole is provided to suppress growth of cancer cells through reduction of expression level of cylin D1. CONSTITUTION: A naphthalenyl phenyl dihydropyrazole compound(3-(2-hydroxynaphthalen-1-yl)-5-(2-methoxyphenyl)-N-(3,4,5-trimethoxyphenyl)-4,5-dihydropyrazole-1-carbothioamide) or a pharmaceutically acceptable salt thereof is denoted by chemical formula 1. A method for preparing naphthalenyl phenyl dihydropyrazole comprises: a step of dissolving 2-hydroxy-1-acetonaphthone and 2-methoxybensaldehyde in ethanol; a step of adding 50% KOH solution in the mixture solution; a step of stirring at room temperature, and cooling; a step of adding 6N HCl and neutralizing to obtain a chalcone compound; a step of dissolving the chalcone compound in ethanol and adding hydrazine; a step of cooling a perfusate, extracting with ethylacetate, and drying the extract by reduced pressure to obtain a pyrazole compound; a step of dissolving the pyrazole compound and 3,4,5-trimethoxy isothiocyanate in ethanol and refluxing; and a step of cooling the perfusate and filtering by reduced pressure.