IMPROVED PREPARATION METHOD FOR MITIGLINIDE CALCIUM

摘要

The present invention relates to an improved preparation method for mitiglinide calcium, and more specifically, to a method for effectively preparing mitiglinide calcium useful as a diabetes drug by carrying out a simple manufacturing process comprising the steps of: preparing 2-benzyl-1-imidazole-4-(octahydro-isoindol-2-yl)-butan-1,4-dione as a novel intermediate using 2-benzylsuccinic acid as a starting material; and converting the same into a calcium salt in the presence of a base.