发明名称 |
Bile Acid Recycling Inhibitors for Treatment of Hypercholemia and Cholestatic Liver Disease |
摘要 |
Provided herein are methods of treating or ameliorating hypercholemia or a cholestatic liver disease by administering to an individual in need thereof a therapeutically effective amount of an Apical Sodium-dependent Bile Acid Transporter Inhibitor (ASBTI) or a pharmaceutically acceptable salt thereof. Also provided are methods for treating or ameliorating a liver disease, decreasing the levels of serum bile acids or hepatic bile acids, treating or ameliorating pruritis, reducing liver enzymes, or reducing bilirubin comprising administering to an individual in need thereof a therapeutically effective amount of ASBTI or a pharmaceutically acceptable salt thereof.
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申请公布号 |
US2013108573(A1) |
申请公布日期 |
2013.05.02 |
申请号 |
US201213662283 |
申请日期 |
2012.10.26 |
申请人 |
LUMENA PHARMACEUTICALS, INC.;LUMENA PHARMACEUTICALS, INC. |
发明人 |
GEDULIN BRONISLAVA;GREY MICHAEL;O'DONNELL NIALL |
分类号 |
A61K31/554;A61K31/155;A61K31/38;A61K31/40;A61K31/4436;A61K31/4453;A61K31/454;A61K31/495;A61K31/4995;A61K31/5377;A61K31/7042;A61K45/06;C07C257/10;C07D207/04;C07D211/08;C07D285/36;C07D337/08;C07D401/12;C07D413/12;C07D487/08;C07H15/26 |
主分类号 |
A61K31/554 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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