摘要 |
The invention is directed to substituted heteroaryl derivatives. Specifically, the invention is directed to compounds according to Formula Q: wherein D, L, M, W, X, Y, and Z are defined herein. The compounds of the invention are inhibitors of DNA methyltransferase (DNMT) activity - including DNMT1, DNMT3a, or DNMT3b - and are useful in the treatment of cancer and hyperproliferative diseases. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting DNMT activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. |
申请人 |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENTLIMITED;HENDRICKSON, THOMAS, FRANCIS;HO, KOC-KAN;SAUNDERS, MICHAEL, DAVID;STEVENS, BRIAN, JOHN;SWIERCZEK, KRZYSZTOF;WRIGHT, KEVIN, BRET |
发明人 |
HENDRICKSON, THOMAS, FRANCIS;HO, KOC-KAN;SAUNDERS, MICHAEL, DAVID;STEVENS, BRIAN, JOHN;SWIERCZEK, KRZYSZTOF;WRIGHT, KEVIN, BRET |