Genetically Modified Major Histocompatibility Complex Mice

摘要

The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II alpha and beta polypeptides), as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.