发明名称 |
GIGAXONIN FUSION PROTEIN AND METHODS FOR TREATING GIANT AXONAL NEUROPATHY |
摘要 |
The present disclosure relates generally to fusion proteins including gigaxonin coupled to a cell penetrant peptide. These fusion proteins can be used to treat GAN in a subject in need thereof. Administration of the fusion proteins allows for control of at least one of Galectin-1 (GAL-1) levels and phosphorylated vimentin protein levels, thereby mediating aggregation of vimentin and the formation of vimentin-free zones in cells. |
申请公布号 |
WO2013063309(A1) |
申请公布日期 |
2013.05.02 |
申请号 |
WO2012US61979 |
申请日期 |
2012.10.25 |
申请人 |
INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION |
发明人 |
PAYNE, R. MARK;BABBEY, CLIFFORD M.;MARTIN, KYLE B.;BEARD, SAMUEL M. |
分类号 |
C07K19/00;A61K38/17;A61P25/00 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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