发明名称 |
METHODS OF TREATING GRAM-NEGATIVE MICROBIAL INFECTIONS |
摘要 |
Provided herein are methods and compositions for treatment of a microbial infection or a microbial biofilm in a subject or on a surface by administering to the subject or surface determined to have or suspected of having a microbial infection/film an antimicrobial agent in combination with a silver-containing compound (e.g., a silver salt). In some embodiments, a silver-containing compound can increase activity of the antimicrobial agent. In other embodiments, addition of a silver-containing compound to an antimicrobial agent can expand the antimicrobial spectrum of the antimicrobial agent such that the antimicrobial agent originally indicated for treatment of one microbial strain (e.g., Gram-positive microbes) becomes effective for treating additional microbial strains (e.g., Gram-negative microbes). Other aspects relating to methods and compositions for delivering an agent to a microbe by increasing the membrane permeability of the microbe are also provided herein. |
申请公布号 |
WO2013063405(A1) |
申请公布日期 |
2013.05.02 |
申请号 |
WO2012US62138 |
申请日期 |
2012.10.26 |
申请人 |
TRUSTEES OF BOSTON UNIVERSITY;COLLINS, JAMES J.;MORONES-RAMIREZ, J. RUBEN;WINKLER, JONATHAN;SPINA, CATHERINE S. |
发明人 |
COLLINS, JAMES J.;MORONES-RAMIREZ, J. RUBEN;WINKLER, JONATHAN;SPINA, CATHERINE S. |
分类号 |
A61K33/38;A61K38/12;A61K38/14;A61P31/04 |
主分类号 |
A61K33/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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