| 摘要 |
<p>The present invention relates to the field of medical devices and surgical implants. Embodiments of the invention provide scaffolds, including biomimetic soft tissue scaffolds, grafts, and prostheses. A nanoporous scaffold is provided comprising a plurality of pores ranging in size from 300 micron to 3 mm, a porosity ranging from 20-80%, and a tensile strength ranging from about 60 N/cm to about 200 N/cm. In embodiments the scaffolds are grown in a manner to comprise at least some of the pores, for example, by delivering oxygen through an array of porous capillaries contacting a culture medium inoculated with a cellulose generating bacteria. Specific embodiments of the invention can be used as biocompatible materials for tissue engineering and regenerative medicine, implants, surgical meshes, biomedical devices and health care products and, more particularly, to biomimetic honeycomb structured soft tissue scaffolds for use in reconstructive surgery.</p> |
