发明名称 |
TNF-alpha binding proteins |
摘要 |
TNF-α binding proteins, including chimeric, CDR-grafted, and humanized antibodies that bind TNF-α are provided. Binding proteins have high affinity for TNF-α and neutralize TNF-α activity. A binding protein can be a full-length antibody or a TNF-α-binding portion thereof. Methods of making and methods of using the binding proteins are also described. The TNF-α binding proteins are useful for detecting TNF-α and for inhibiting TNF-α activity, including in a human subject suffering from a disease or disorder in which TNF-α activity is detrimental. |
申请公布号 |
AU2011338313(A1) |
申请公布日期 |
2013.05.02 |
申请号 |
AU20110338313 |
申请日期 |
2011.12.08 |
申请人 |
ABBOTT GMBH & CO KG;ABBOTT LABORATORIES |
发明人 |
HSIEH, CHUNG-MING;GOODREAU, CARRIE;GHAYUR, TARIQ;MOELLER, ACHIM;BOSE, SAHANA |
分类号 |
C12P21/06 |
主分类号 |
C12P21/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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