| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide novel pegylated proteins, and to provide their methods of making and use. <P>SOLUTION: An erythropoietin protein is linked to one polyethylene glycol molecule or is linked to two polyethylene glycol molecules. Covalent linkage to at least one polyethylene glycol molecule via the amino terminus of the erythropoietin protein is not through an aldehyde linkage. The invention comprises a composition having at least one erythropoietin molecule covalently linked to at least one polyethylene glycol molecule through a particular lysine residue, which residue is lysine 116. <P>COPYRIGHT: (C)2013,JPO&INPIT |
