METHOD FOR PRODUCING 1&bgr;-METHYLCARBAPENEM

摘要

PROBLEM TO BE SOLVED: To provide a new production method by culturing a microorganism of an 1β-methylcarbapenem based compound.

SOLUTION: A useful 1β-methylcarbapenem based compound as a medicine or a raw material for medicines by culturing a microorganism producing a carbapenem based compound, particularly a thienamycin producer in a medium including a (2S,4S)-4-methylglutamic acid analog, and isolating the 1β-methylcarbapenem based compound from the culture.

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