发明名称 |
Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences |
摘要 |
<p>A non-toxic mutant form of the Vibrio cholera Cholix gene (ntCholix), a variant of Cholix truncated at amino acid A386 (Cholix386) and the use of other various Cholix-derived polypeptide sequences to enhance intestinal delivery of biologically-active pharmaceutical, therapeutics. The systems and methods described herein provide for the following: the ability to deliver macromolecule doses without injections; the ability to deliver cargo, such as (but not limited to) siRNA or antisense molecules into intracellular compartments where their activity is required; and the delivery of nanoparticles and dendrimer-based carriers across biological membranes, which otherwise would have been impeded due to the barrier properties of most such membranes.</p> |
申请公布号 |
AU2011302645(A1) |
申请公布日期 |
2013.05.02 |
申请号 |
AU20110302645 |
申请日期 |
2011.09.15 |
申请人 |
MAHMOOD, TAHIR;MRSNY, RANDALL J |
发明人 |
MRSNY, RANDALL J;MAHMOOD, TAHIR |
分类号 |
A61K9/00 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|