Certain imidazopyrazines and pharmaceutical compositions thereof are provided herein. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of Syk activity, which comprises administering to such 5 patients an amount of at least one chemical entity effective to reduce signs or symptoms of the disease or disorder are provided. Also provided are methods for determining the presence or absence of Syk kinase in a sample.
申请公布号
AU2013205339(A1)
申请公布日期
2013.05.02
申请号
AU20130205339
申请日期
2013.04.11
申请人
GILEAD CONNECTICUT, INC.
发明人
MITCHELL, SCOTT A.;CURRIE, KEVIN S.;GREN, PETER A.;KROPF, JEFFREY E.;LEE, SEUNG H.;XU, JIANJUN;STAFFORD, DOUGLAS G.;HARDING, JAMES P.;BARBOSA JR., ANTONIO J.;ZHAO, ZHONGDONG