USES OF INDOLE-KETONES OR INDOLIDONES AS NEURO-PROTECTIVE DRUGS

摘要

The present invention provides a method of using indole-ketone or mdolidone to treat or prevent a neurodegenerative disease or disorder. In one embodiment, the neurodegenerative disease is Parkinson's disease. In another embodiment, the neurodegenerative disease or disorder is associated with excessive neuronal Nitric Oxide Synthase (nNOS) activity. Examples of indole- ketone include, but are not limited to, SU4312, SU5416, SU1 1248 (Sumtimb), and indirubm-3- oxime.