发明名称 |
Biological Bypass Bridge with Sodium Channels, Calcium Channels and/or Potassium Channels to Compensate for Conduction Block in the Heart |
摘要 |
This invention provides a bypass bridge comprising a tract of gap junction-coupled cells having a first end and a second end, both ends capable of being attached to two selected sites in a heart so as to allow the conduction of a pacemaker and/or electrical signal/current across the tract between the two sites, wherein the cells functionally express a sodium channel. The invention also provides related methods of making the bypass bridge, methods of implanting same in a heart, and methods of treating a disorder associated with an impaired conduction in a subject's heart.
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申请公布号 |
US2013110218(A1) |
申请公布日期 |
2013.05.02 |
申请号 |
US201213535013 |
申请日期 |
2012.06.27 |
申请人 |
ROSEN MICHAEL R.;BRINK PETER R.;COHEN IRA S.;ROBINSON RICHARD B.;DANILO, JR. PETER;THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK;THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
ROSEN MICHAEL R.;BRINK PETER R.;COHEN IRA S.;ROBINSON RICHARD B.;DANILO, JR. PETER |
分类号 |
A61N1/05;C12N5/077;C12N5/0775 |
主分类号 |
A61N1/05 |
代理机构 |
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主权项 |
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地址 |
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