发明名称 Process for the Preparation of Dronedarone
摘要 This disclosure relates to a process for the preparation of N-[2-n-butyl-3-{4-[(3-dibutylamino)-propoxy]-benzoyl}-1-benzofuran-5-yl]-methane-sulfonamide of formula I and its pharmaceutically acceptable salts, wherein one of the methylsulfonyl groups of the 2-n-butyl-3-[(di-n-butylamino-3-propoxy)-benzoyl]-5-bis-(methylsulfonamido)-benzofuran of formula II is selectively cleaved and if desired, the resulting compound of formula I is transformed into its salt.
申请公布号 US2013109868(A1) 申请公布日期 2013.05.02
申请号 US201213711891 申请日期 2012.12.12
申请人 SANOFI;SANOFI 发明人 FRIESZ ANTAL
分类号 C07D307/80 主分类号 C07D307/80
代理机构 代理人
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