发明名称 |
Genetically Modified Major Histocompatibility Complex Mice |
摘要 |
The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I polypeptide and/or human or humanized beta2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.
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申请公布号 |
US2013111617(A1) |
申请公布日期 |
2013.05.02 |
申请号 |
US201213661159 |
申请日期 |
2012.10.26 |
申请人 |
REGENERON PHARMACEUTICALS, INC.;REGENERON PHARMACEUTICALS, INC. |
发明人 |
MACDONALD LYNN;MURPHY ANDREW J.;GURER CAGAN;MCWHIRTER JOHN;VORONINA VERA;HARRIS FAITH;STEVENS SEAN |
分类号 |
A01K67/027;A01K67/02;C12N15/06 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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