Modified Polymers for Delivery of Polynucleotides, Method of Manufacture, and Methods of Use Thereof

摘要

A modified polymer is provided herein, the modified polymer having the following formula: in which W1, W2, W3, W4, W5, W6, Z1, Z2, Z3, Z4, Z5, Z9', R1, R2, R3, R4, R5, n1, n2, n3, n4, n5, and n6' are defined herein. The modified polymer is useful for delivering a polynucleotide to the cytoplasm of a selected tissue type or cell type.