USE OF EGFL7 MODULATORS FOR PROMOTING OR INHIBITING MIGRATION OF IMMUNE CELLS ACROSS VASCULAR ENDOTHELIUM

摘要

The present invention relates to a method of modulating transmigration of immune cells across vascular epithelium. More particularly, the present invention addresses two different types of situations. In conditions where an upregulation of immune cells extravasation is needed, for example in cancers, Egfl7 antagonists are used. In conditions where a downregulation of leukocytes transendothelial migration is preferred, for example in pathological inflammation, Egfl7 or an agonist thereof is used.