IONOPHORE ANTIBIOTIC VETERINARY COMPOSITION AND METHOD OF MANUFACTURE

摘要

The present invention relates to an ionophore antibiotic composition in the form of a water dispersible granule which is a dry flowable formulation capable of direct dispersion in the drinking water of animals (i.e. via trough treatment). The ionophore antibiotic remains in a substantially stable solution uniformly dispersed in the drinking water for up to 62 days and thus provides a safe and practical form of treatment. The formulation is also capable of being mixed with water for oral administration by drenching. The water dispersible granule composition comprises at least one ionophore antibiotic (preferably monensin), at least one filler-binder, at least one surfactant, at least one dispersing agent, and at least one disintegrant. The ionophore antibiotic is preferably micronized before inclusion in the composition. The invention also relates to a method of manufacturing the composition comprising a dry milling step to reduce the particle size of the ionophore antibiotic to less than 30 microns, a mixing step and a dry granulation step.