Combination of biomarkers for detecting and evaluating a hepatic fibrosis

摘要

The application relates to means for determining the stage of hepatic tissue damage, in particular the hepatic fibrosis score, of individuals infected with one or more hepatitis viruses. The means of the invention implement in particular the assay of the expression levels of selected genes, said selected genes being: - SPP1, and - at least one gene among A2M and VIM, and - at least one gene among IL8, CXCL10 and ENG, and - optionally, at least one gene among the list of the following sixteen genes: IL6ST, p14ARF, MMP9, ANGPT2, CXCL11, MMP2, MMP7, S100A4, TIMP1, CHI3L1, COL1A1, CXCL1, CXCL6, IHH, IRF9 and MMP1.