发明名称 High throughput screening method and use thereof to identify a production platform for a multifunctional binding protein
摘要 Methods of identifying and expressing an antibody variant are disclosed wherein the method comprises identifying a binding region in an antibody, fusing the binding region to a plurality of scaffolds of antibody constant regions to obtain antibody fragment variants, expressing the antibody fragment variants in organisms to form constructs and expressing the constructs carried by the organisms to form induced cultures, wherein the organisms are expressed in HTP mode.
申请公布号 AU2009266989(B2) 申请公布日期 2013.05.02
申请号 AU20090266989 申请日期 2009.07.01
申请人 PFENEX, INC. 发明人 RETALLACK, DIANE
分类号 C12N15/62;C12N15/78;G01N33/50 主分类号 C12N15/62
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