c-Met modulators and methods of use

摘要

C:lNRPonIbimCOJAMUII7f42_l.DOC-2627/2 0 The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed 5 cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. 10 The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.