| 摘要 |
A targeted therapy associates nanoparticles (20, figure 6a) with target cells (10) (such as tumour cells) and exposes them to a time varying electric field (22) sufficient to cause non thermal electroporation of the cells. The electroporation may be reversible or irreversible depending on the strength of the applied field. The nanoparticles are conductive or high permittivity and enhance the electric field. They may be made from a metal or a metal oxide and are preferably iron oxide, gold, silver or platinum. The particles may have a coating containing antibodies, aptamers or ligands which bind preferentially to receptors on the target cells. The coating may be uniform over the surface or it may be located on a specific region of the particle to promote binding in a preferred orientation. Electrodes 110,112 may be located outside of the body or may be implanted or the method may be used in vitro (figures 17 & 18). |
