发明名称 |
Improvements to matrix assisted laser desorption ionisation mass spectrometry imaging (maldi-msi) |
摘要 |
<p>A method for preparing a matrix assisted laser desorption ionisation mass spectrometry imaging (MALDI-MSI) sample comprises: dusting a sample with a MALDI-MSI matrix powder; removing excess powder from the sample, and spraying the dusted sample with a solvent in which both the matrix powder and the sample are soluble. Preferably, the sample is a fingermark, and the sample is lifted from a surface upon which the sample is deposited using an adhesive backed strip, pad or tape. The prepared sample may be introduced into a MALDI imaging mass spectrometer, a laser beam delivered to the sample and an image generated. A fluorescent or UV image of the prepared sample may be obtained. The MALDI-MSI matrix may be 4-hydroxycinnamic acid. The solvent may comprise a mixture of trifluoroacetic acid and acetonitrile.</p> |
申请公布号 |
GB2489215(B8) |
申请公布日期 |
2013.05.01 |
申请号 |
GB20110004365 |
申请日期 |
2011.03.15 |
申请人 |
SHEFFIELD HALLAM UNIVERSITY |
发明人 |
LEESA SUSANNE FERGUSON;ROSALIND WOLSTENHOLME;SIMONA FRANCESE |
分类号 |
G01N1/28;A61B5/117;G01N33/68 |
主分类号 |
G01N1/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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