发明名称 |
PROCESS FOR PREPARING CREATINE AMIDES |
摘要 |
<p>The invention relates to the field of pharmaceutical chemistry, specifically to processes for preparing biologically active substances (BAS), in particular creatine amides. What is proposed is a process for preparing creatine amides which comprises treating creatine with para-toluenesulfonic acid in an organic solvent with subsequent reaction of the resultant complex with compounds comprising a primary or secondary amino group in the presence of a condensing agent and a base which are introduced subsequently. The claimed process makes it possible to increase the yield of the end product by 2-5 times in comparison with analogs and also to extend the range of the compounds prepared.</p> |
申请公布号 |
EP2497765(A4) |
申请公布日期 |
2013.05.01 |
申请号 |
EP20100828601 |
申请日期 |
2010.09.28 |
申请人 |
ZAKRYTOE AKTSIONERNOE OBSCHSHESTVO "VERTEX" |
发明人 |
BUROV, SERGEJ VLADIMIROVICH;VESELKINA, OLGA SERGEEVNA;LEKO, MARIA VICTOROVNA |
分类号 |
C07C277/08;C07C279/10;C07C279/12;C07K5/062 |
主分类号 |
C07C277/08 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|