发明名称 |
MODIFIED PEPTIDE VACCINE DERIVED FROM INFLUENZA M2 |
摘要 |
A modified peptide derived from matrix protein 2 (hereinafter also referred to as "M2"), one of surface layer proteins of influenza virus, and a method for utilization of the modified peptide are provided. A peptide (hereinafter also referred to as "M2eC peptide") that is made up by inserting cysteine residue(s) into a peptide (hereinafter also referred to as "M2e") consisting of 23 amino acid residues of from positions No. 2 to No. 24 of M2 in influenza virus type A, a fusion protein consisting of said modified peptide and a polypeptide, an influenza vaccine comprising said modified peptide or said fusion protein as an active ingredient, a device which can be delivered into the body comprising said influenza vaccine, a nucleic acid fragment consisting of a nucleotide sequence encoding the amino acid sequence of said modified peptide or said fusion protein, an expression vector in which said nucleic acid fragment is incorporated, a host in which said expression vector is introduced, and an antibody that has a protective effect against influenza virus. |
申请公布号 |
EP2471915(A4) |
申请公布日期 |
2013.05.01 |
申请号 |
EP20100811798 |
申请日期 |
2010.08.23 |
申请人 |
THE CHEMO-SERO-THERAPEUTIC RESEARCH INSTITUTE |
发明人 |
KAMINAKA, KAZUYOSHI;NOZAKI, CHIKATERU;MATSUDA, JUNICHI;NISHIYAMA, KIYOTO |
分类号 |
C12N15/09;A61K39/145;A61K39/155;A61P31/16;C07K14/005;C07K14/11;C07K16/10;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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