| 摘要 |
<p>COMPOUNDS OF FORMULA (I) HAVE ANTIBACTERIAL ACTIVITY WHEREIN R REPRESENTS HYDROGEN OR 1, 2 OR 3 OPTIONAL SUBSTITUENTS; W IS =C(R1)- OR =N-; R1 IS HYDROGEN OR AN OPTIONAL SUBSTITUENT AND R2 IS HYDROGEN, METHYL, OR FLUORINE; OR R1 AND R2 TAKEN TOGETHER ARE -CH2-, -CH2CH2-, -O-, OR, IN EITHER ORIENTATION, -O- CH2- OR -OCH2CH2-; R3 IS A RADICAL OF FORMULA -(ALK1)M-(Z)P-(ALK2)N-Q WHEREIN M, P AND N ARE INDEPENDENTLY 0 OR 1, PROVIDED THAT AT LEAST ONE OF M, P AND N IS I, Z IS -O-, -S-, -S(O)-, -S(O2)-, -NH-, -N(CH3)-,-N(CH2CH3)-, -C(=O)-, -O-(C=O)-, -C(=O)-O-, OR AN OPTIONALLY SUBSTITUTED DIVALENT MONOCYCLIC CARBOCYCLIC OR HETEROCYCLIC RADICAL HAVING 3 TO 6 RING ATOMS; OR AN OPTIONALLY SUBSTITUTED DIVALENT BICYCLIC HETEROCYCLIC RADICAL HAVING 5 TO 10 RING ATOMS; ALK1 AND ALK2 ARE OPTIONALLY SUBSTITUTED C1C6 ALKYL ENE, C2-C6 ALKENYLENE, OR C2-C6 ALKYNYLENE RADICALS, WHICH MAY OPTIONALLY TERMINATE WITH OR BE INTERRUPTED BY -O-, -S-, -S(O)-, -S(O2)-, -NH-, -N(CH3)-, OR -N(CH2CH3)-; AND Q IS HYDROGEN, HALOGEN, NITRILE, OR HYDROXYL OR AN OPTIONALLY SUBSTITUTED MONOCYCLIC CARBOCYCLIC OR HETEROCYCLIC RADICAL HAVING 3 TO 6 RING ATOMS; OR AN OPTIONALLY SUBSTITUTED BICYCLIC HETEROCYCLIC RADICAL HAVING 5 TO 10 RING ATOMS.</p> |
