发明名称 C-21-keto lupane derivatives preparation and use thereof
摘要 The invention relates to 21-keto triterpene compounds of formula (I): wherein R1, X and Y are as defined herein, and pharmaceutically acceptable salts and solvates thereof. These compounds exhibit significant anti-HIV activity. Thus, the invention also relates to methods for prevention or treatment of HIV infections by administering therapeutically effective amounts of a compound of formula (I), or a pharmaceutically acceptable salt or solvate thereof to a subject in need of such treatment.
申请公布号 US8431556(B2) 申请公布日期 2013.04.30
申请号 US20100830294 申请日期 2010.07.03
申请人 MOINET CHRISTOPHE;COURCHESNE MARC;HALAB LILIANE;CHAURET NATHALIE;KONG LAVAL CHAN CHUN;VERTEX PHARMACEUTICALS INCORPORATED 发明人 MOINET CHRISTOPHE;COURCHESNE MARC;HALAB LILIANE;CHAURET NATHALIE;KONG LAVAL CHAN CHUN
分类号 A61K31/56;C07J53/00 主分类号 A61K31/56
代理机构 代理人
主权项
地址