COMPOUNDS WHICH HAVE ACTIVITY AT M? RECEPTOR AND THEIR USES IN MEDICINE

摘要

COMPOUNDS OF FORMULA (I) AND SALTS AND SOLVATES ARE PROVIDED: WHEREIN R? IS FLUORO, R? IS SELECTED FROM HYDROGEN, HALOGEN, CYANO, C?-?ALKYL, C?-?ALKYL SUBSTITUTED WITH ONE OR MORE FLUORINE ATOMS, C?-?ALKOXY, AND C?-?ALKOXY SUBSTITUTED WITH ONE OR MORE FLUORINE ATOMS, AND R? IS SELECTED FROM HALOGEN, CYANO, C?-?ALKYL, C?-?ALKYL SUBSTITUTED WITH ONE OR MORE FLUORINE ATOMS, C? -?CYCLOALKYL, C? -?CYCLOALKYL SUBSTITUTED WITH ONE OR MORE FLUORINE ATOMS, C?-?ALKOXY AND C?-?ALKOXY SUBSTITUTED WITH ONE OR MORE FLUORINE ATOMS, AND Q IS HYDROGEN OR C?-?ALKYL. THE COMPOUNDS ARE EXPECTED TO BE USEFUL FOR THERAPY, FOR EXAMPLE IN THE TREATMENT OF PSYCHOTIC DISORDERS AND COGNITIVE IMPAIRMENT.