| 摘要 |
<p num="1"><br/><br/><br/>Histone deacetylase is a metallo-enzyme with zinc at the active site. <br/>Compounds having a zinc-binding moiety, for example, an alpha-ketoepoxide <br/>group, such as an alpha-ketothio group, can inhibit histone deacetylase. <br/>Histone deacetylase inhibition can repress gene expression, including <br/>expression of genes related to tumor suppression. Accordingly, inhibition of <br/>histone deacetylase can provide an alternate route for treating cancer, <br/>hematological disorders, e.g., hemoglobinopathies, autosomal dominant <br/>disorders, e.g., spinal muscular atrophy and Huntington''s disease, genetic <br/>related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy, <br/>or to stimulate hematopoietic cells ex vivo.<br/>
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