发明名称 |
Methods for modulating the proliferation and differentiation potential of stem cells and progenitor cells |
摘要 |
Modulators of TRIM-NHL proteins and their use for modulating the proliferation and differentiation potential of stem cells and progenitor cells. Inhibitors of TRIM-NHL proteins, e.g. TRIM32, are useful for stem cell maintenance in vitro and in vivo. Assay methods for identifying TRIM-NHL protein modulators make use of the E3 ligase activity of TRIM32 or its interaction with Argonaute-1. |
申请公布号 |
US8431398(B2) |
申请公布日期 |
2013.04.30 |
申请号 |
US20080680493 |
申请日期 |
2008.09.19 |
申请人 |
KNOBLICH JUERGEN;SCHWAMBORN JENS;IMBA-INSTITUT FUR MOLEKULARE BIOTECHNOLOGIE GMBH |
发明人 |
KNOBLICH JUERGEN;SCHWAMBORN JENS |
分类号 |
C12N5/02;C12N5/0797;C12N15/13 |
主分类号 |
C12N5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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