| 发明名称 |
Method for treating pruritus comprising administering an NR10 antagonist |
| 摘要 |
The present inventors isolated clone BM095 from a human antibody phage library, which had a strong growth inhibitory activity in the IL-31-dependent Ba/F3 cell growth assay system. When administered to pruritus model mice, the anti-mouse NR10 neutralizing antibody exhibited a marked symptom-suppressing effect. Thus, it was revealed that anti-NR10 neutralizing antibodies are useful as therapeutic agents for pruritus. |
| 申请公布号 |
US8431127(B2) |
申请公布日期 |
2013.04.30 |
| 申请号 |
US20080746229 |
申请日期 |
2008.12.05 |
| 申请人 |
HIGUCHI YOSHINOBU;KASUTANI KEIKO;KITAMURA HIDETOMO;HASEGAWA MASAKAZU;CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
HIGUCHI YOSHINOBU;KASUTANI KEIKO;KITAMURA HIDETOMO;HASEGAWA MASAKAZU |
| 分类号 |
A61K39/395;C07K16/28 |
主分类号 |
A61K39/395 |
| 代理机构 |
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